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| Medication and Depression |
In my decade of private practice working with clients across 20+ countries, this is one of the most common questions I hear. The answer isn't simple, but understanding your options will help you make the right choice for you.
In this piece, I look at medication, talk therapy, and studies that examine both. But it's a long read and you're busy, so I kick off with a quick summary. Then, if you have time, you can dive in.
Science Summary
Good news is that depression is very treatable. The American Psychiatric Association reports that 70% to 90% of people with depression eventually respond well to treatment.
But it's not a one-size-fits-all instant fix.
Medication works better than doing nothing. Roughly 50% of people with depression can see their doctor, pop a pill, and after 8 weeks find they're experiencing significant improvement.
Talk therapy works better than doing nothing. Roughly 46% of people with depression can talk to a therapist once a week and report significant improvement after 8 weeks.
BUT thinking you'll fix depression in 8 weeks is a bit unrealistic. Pills can work a bit quicker at first, but if you look at results after a few months, people find talk therapy slightly better than medication for improving quality of life.
My Clinical Perspective
I think of depression as spots: you may have spots because you have chickenpox, an allergy to soap, you lost your job, or more. Depression can be a condition but it can also be a symptom.
Figuring out what's causing it will lead you to the appropriate action. There's no point in changing your soap if you have chickenpox.
Depression is the same. There are lots of different causes and that's why there are various approaches for managing it. There's not one-size-fits-all.
In my clinical experience, most studies don't adequately differentiate between types of depression. They treat it as one uniform condition, which limits how useful their conclusions can be for individual cases.
What I've observed across hundreds of clients is this: before you do anything, you should try and figure out what's going on.
If you are depressed because of your life circumstances, a pill may help with mood but it won't change your life circumstances. This is where talk therapy becomes essential.
For all depression, talk therapy will help you learn tools that you can use all your life.
However, if you are so down that you can't function, medication can help give you the mental space to start working for effective change.
Also, if you have regular cycles of depression, then meds can be helpful to balance your mood.
Finally, if you are suicidal, talking to your doctor is a must. Here are six questions to ask them.
Bottom line: if you are not suicidal, try talk therapy first and then you can always look at meds later.
If you're unsure where to start, this is exactly what we explore in initial consultations. Send me an email and let's talk about what's happening for you.
And now, the big discussion!
Depression: Talking About Medication
In theory, you're depressed which involves your body, specifically your brain. If you have an infection, you take a pill to fix that, so if you're depressed, taking medication will help fix it. Easy, right?
In practice, it's a bit trickier.
There are about 20 commonly available antidepressants on the market. What different people respond to varies considerably, which is why finding the right medication often involves trial and error.
How successful is medication?
Important fact: antidepressants take between 2 and 8 weeks to start working. People don't always know this, so many of them pop a pill, think it doesn't work, and quit after a day or so.
Medication takes time to work.
Typically, if you prescribe antidepressants to 100 people and ask them how it's going after 8 weeks:
- 50 people will be happy with the results. The other 50 will not.
- Of the ones who are not happy, many will say they feel no difference at all.
- Some will say they feel a bit of difference but it's not a game changer.
- And some will say they feel a difference but they're also experiencing side effects such as insomnia, fatigue, and loss of appetite.
As there are different medications and doses available, a doctor may either adjust the dosage or prescribe a different brand. Then you wait another 8 weeks. Typically, half of those remaining will then be happy with the results and the other half not.
Although people with severe depression will persist through trying different brands and doses, many people become frustrated with the process and give up.
Also, research suggests that 30% of people have treatment-resistant depression, meaning current medications don't help them.
In 2018, researchers at Oxford University conducted a meta-analysis of 432 randomized controlled trials involving 116,477 people and reported that any kind of antidepressant is more effective than placebos.
The takeaway: Medication is useful, better than doing nothing. If you want to read up, there is the UK National Health Service overview of antidepressants and USA National Library of Medicine Depression: Learn More.
Depression: Talking About Talk Therapy
Depression being like spots means the experience is not the same for everyone. And if that's not complicated enough, you may find that your depression changes according to your age and circumstances.
What is a constant is that depression lies to us: it tells us life sucks, it promotes sadness and anger, makes us blind to daily happiness, stops us doing fun things, messes with our sleep, raises our anxiety, twists appetite, and causes general havoc.
During psychotherapy, I help you identify how your depression works, and then we work together to figure out a system that will help you push back. We develop strategies tailored to your specific situation—not a generic approach, but tools that work for how depression shows up in your life.
Many of my clients initially felt overwhelmed by this choice between medication and therapy. What they discovered through our work together was that understanding their depression gave them power over it, regardless of whether they also used medication.
How successful is talk therapy?
That's a really hard question to answer because there are dozens of different talk therapy systems. Each one has a different philosophy, a different approach, and as therapists are human and not robots, how it's delivered is different too.
Plus, there's politics involved. One particular approach, Cognitive Behavioural Therapy (CBT), has a philosophy that lends itself to automation. As hospitals and apps use that to create bots and apps (much cheaper than employing people!) it is the one that's pushed most.
I like CBT (you can read why and how it works here) but what concerns me is that research is biased because many studies take place in hospitals that only offer CBT, so other approaches are often excluded from the evidence base.
However, I have a nice study for you. In 2021, researchers from Vrije Universiteit Amsterdam, Netherlands conducted a meta-analysis of 331 trials involving 34,285 people comparing all kinds of therapies.
They analysed studies that used cognitive-behavioural, interpersonal, psychodynamic, problem-solving, behavioural activation, life-review, and "third wave" therapies like mindfulness.
They also reviewed 'supportive counselling' which is based on being nice and listening. Often this is what untrained volunteers at charities do, but some therapists offer it too.
Then they compared all these approaches to doing nothing, waiting lists, and placebo pills.
They reported that:
- Doing something is better than doing nothing, waiting, or taking a placebo pill.
- All the various therapy approaches yielded similar results.
- Supportive counselling had some effect but wasn't as useful as having a structured therapy approach.
The researchers concluded that most therapies work well for treating adult depression, and differences are small. Choosing a useful therapy may depend more on personal preferences, availability, or tailoring treatment to the individual.
What Next?
Here's what I tell my clients: when it comes to managing adult depression, the choice of whether to pop a pill or go for talk therapy is often less about which method is theoretically most effective and more about finding the right fit for you and your specific situation.
In my clinical experience:
If your depression stems from life circumstances—job loss, relationship problems, major life transitions—talk therapy should be your first step. Medication may help you feel better temporarily, but it won't resolve the underlying issues or teach you the skills to navigate them.
If you're so depressed you can barely function, combining medication and therapy often works best. The medication can lift you enough to engage meaningfully in therapy, where you'll develop lasting tools for managing depression.
If you have cyclical depression or a family history of mood disorders, this suggests a biological component. You may benefit from medication alongside therapy to address both the neurochemical and psychological aspects.
If you're not sure what's causing your depression, start with talk therapy. Through our work together, we'll figure out what's driving your depression and what intervention makes sense for you. You can always add medication later if needed.
The decision doesn't have to be permanent or perfect. Many people start with one approach and adjust as they learn more about what works for them.
If you want to explore talk therapy and see if it's right for you, message me today via email ellen.whyte@gmail.com or WhatsApp: +44 7514 408143 for your free 15-minute consultation.
Updated: 2nd October 2025
